Table 3.
Univariable and multivariable Cox proportional analyses of factors associated with OS
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P value | HR | (95% CI) | P value | |
| Age | 1.01 | 1.00–1.02 | 0.065 | 1.01 | 1.00–1.02 | 0.08 |
| Male | 0.95 | 0.76–1.19 | 0.669 | |||
| Tumor size | 1.08 | 1.05–1.11 | <0.001 | 1.03 | 0.99–1.06 | 0.127 |
| Site | ||||||
| Non-GEJ | Ref | Ref | ||||
| Gastro-Esophageal Junction (GEJ) | 1.77 | 1.22–2.59 | 0.003 | 1.79 | 1.19–2.70 | 0.005 |
| Histologic Grade | ||||||
| Well to Moderate | Ref | |||||
| Moderate to Poor | 1.19 | 0.93–1.52 | 0.163 | |||
| Depth of Invasion | ||||||
| T1-T2 | Ref | Ref | ||||
| T3-T4 | 2.47 | 1.92–3.18 | <0.001 | 2.08 | 1.54–2.80 | <0.001 |
| Margin | ||||||
| R0 | Ref | Ref | ||||
| R1 | 1.69 | 1.17–2.44 | 0.005 | 0.89 | 0.60–1.31 | 0.547 |
| LNR | ||||||
| ≤0.25 | Ref | Ref | ||||
| >0.25 | 2.58 | 2.07 | <0.001 | 2.33 | 1.79–3.03 | <0.001 |
| Lymphovascular Invasion | 1.98 | 1.56–2.50 | <0.001 | 1.4 | 1.09–1.79 | 0.008 |
| Operation Type | ||||||
| Subtotal | Ref | Ref | ||||
| Total | 1.49 | 1.20–1.86 | <0.001 | 1.25 | 0.98–1.60 | 0.073 |
| Extent of Lymphadenectomy | ||||||
| D0/D1 | Ref | Ref | ||||
| D2/D3 | 0.75 | 0.60–0.93 | 0.01 | 0.8 | 0.63–1.00 | 0.051 |
| Adjuvant Therapy | ||||||
| None | Ref | Ref | ||||
| CTx | 1.34 | 1.00–1.79 | 0.051 | 0.88 | 0.65–1.20 | 0.434 |
| cXRT | 0.8 | 0.63–1.03 | 0.088 | 0.4 | 0.30–0.53 | <0.001 |