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. 2018 Jun 29;14:1619–1636. doi: 10.3762/bjoc.14.138

Scheme 1.

Scheme 1

Left: The Mitsunobu reaction is essentially a nucleophilic substitution of alcohols occurring with inversion of configuration at the alcohol stereocenter. The auxiliary reagents are involved in a redox process. Right: Original correspondence with Professor Oyo Mitsunobu (letter to P.R. in 1993).