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A proposed model for the regulation of IRS4 by CK1γ2. IRS4 generally activates the Akt pathway, and can be phosphorylated at Ser859 by CK1γ2, which in turn promotes the polyubiquitination and subsequent degradation of IRS4 via the CHIP-mediated ubiquitin/lysosome pathway, and consequently impairs the activation of Akt.
