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. 2018 May 24;8(13):3437–3460. doi: 10.7150/thno.23853

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Design and synthesis of self-quenched HPMA copolymer-GFLG-Cy5 (P-GFLG-Cy5), PGA-Cy5 (PC) and FRET-based PGA-Cy5-Quencher (PCQ) Turn-ON probes. (A) Schematic representation of two different pathways of the probes' degradation by cysteine cathepsins, leading to their activation and increase in the fluorescence signal, as the fluorophore molecules are distanced from each other and quenching is terminated. (B) Synthesis scheme of P-GFLG-Cy5 (System 1), PC (System 2) and PCQ (System 3) Turn-ON probes.