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. 2018 Jun 7;8(13):3597–3610. doi: 10.7150/thno.25608

Figure 3.

Figure 3

Cellular uptake and in vitro therapeutic effects of r9-CN and CN in metastatic 4T1 cells. (A) Cellular uptake in 4T1 cells under LCSM; scale bar = 40 µm. (B) Quantified cellular internalization in 4T1 cells determined by flow cytometry; *p < 0.05. (C) Cytotoxicity of CTX, CN, and r9-CN in metastatic 4T1 cells. (D) Percentage of cells migrating across the transwell membrane compared to the negative control; *p < 0.05, **p < 0.01. (E) Typical images of cell migration across the transwell membrane, where cell clusters are illustrated as violet regions; scale bar = 200 µm.