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In vivo therapeutic effects of r9-CN on inhibiting distant lung metastasis of breast cancer. (A) Typical images of lung tissues from PBS, blank r9-N, CTX, CN, and r9-CN groups; white circles denote visually-detected metastatic nodules in the lung. (B) Average number of metastatic nodules in lungs from various formulations; *p < 0.05, **p < 0.01. (C) Histological examinations of whole lung tissues by Hematoxylin and Eosin staining from each group; scale bar = 5000 µm.
