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Intrastriatal injections in adult rats show superior transduction ability and vector spread of AAV-TT across large areas of the CNS. GFP-expressing AAV-TT or AAV2 (both 3.5 × 109 vg) were injected into the striatum of adult rat brains (n = 3). (A) Representative images of GFP signal 4 weeks post-injection in the different brain areas indicated. (B) High magnification images of the sections shown in A. Scale bar = 100 µm.
