Table 1.

Pathway Analysis Showing Over-representation of Gene Ontology Biological Process Terms Related to Inflammation and Cell Cycle in dnTGF-βRII-T2A-Pbbz PSMA CAR T Cells at Days 14 and 21 of Culture

Pathway ID	Pathway Description	Observed Gene Count	False Discovery Rate
Day 14
GO.0034097	response to cytokine	14	8.87E−08
GO.0051707	response to other organism	14	8.87E−08
GO.1903708	positive regulation of hemopoiesis	9	9.32E−08
GO.1902107	positive regulation of leukocyte differentiation	8	4.32E−07
GO.0033993	response to lipid	13	3.61E−06
GO.0032496	response to lipopolysaccharide	9	5.37E−06
GO.0002639	positive regulation of immunoglobulin production	5	5.66E−06
GO.0006954	inflammatory response	10	1.01E−05
GO.0031347	regulation of defense response	12	1.19E−05
GO.0009617	response to bacterium	10	1.44E−05
Day 21
GO.0000278	mitotic cell cycle	67	2.00E−34
GO.1903047	mitotic cell cycle process	57	1.46E−27
GO.0007049	cell cycle	72	7.91E−27
GO.0022402	cell cycle process	62	1.12E−24
GO.0007067	mitotic nuclear division	39	6.56E−24
GO.0051301	cell division	42	8.18E−22
GO.0000280	nuclear division	40	1.50E−21
GO.0048285	organelle fission	41	1.50E−21
GO.0007059	chromosome segregation	27	1.62E−18
GO.0051726	regulation of cell cycle	45	2.17E−13

The top 10 processes are listed; the complete list is shown in Table S3.