Figure 5.

Adult and old T cell decay kinetics in old environments after separation. Data represent the frequency of adult (CD45.1, heterochronic parabiont) or old (CD45.1, isochronic old) cells among the indicated T cell subset in blood, measured longitudinally after separation in CD45.2 old parabionts. Starting % of CD45.1 or CD45.2 within population was normalized to one so decay of population could be directly compared. (A) CD3 T cell kinetics the blood. (B) CD8 kinetics in the blood. (C) CD4 kinetics in the blood. Each group is three to six mice in two independent experiments. Statistical values depict difference in linear regressions, where each slope is tested whether it is significantly different from the other cell type. *p < 0.05, **p < 0.01, ***p < 0.001, ****p <0.0001, and ns is not significant.