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Conjugation of a triarylmethyl (trityl) mass tag to an antibody molecule. Covalent attachment of the trityl mass tag to the primary amine of an antibody is facilitated by the N-hydroxysuccinimide ester group on the trityl molecule. In the MALDI mass spectrometer the trityl group absorbs the energy from the laser, resulting in cleavage of the C–S bond, creation of a stable carbocation, and release of the trityl mass tag
