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Progression in tumor angiogenesis. Hypoxic tumor microenvironment triggers cells to produce and release chemokines and cytokines. The overexpression of growth factors enhances protease production leading to degradation of vessel basal lamina, and modulates endothelial cell migration and proliferation. Tip cell guides the sprouts of new blood vessels towards the stimulus. Recruitment of mural cells and generation of new basal membrane enhance blood vessel maturation.
