Table 6.
Frequency of MMP-2 (-1306 C/T) genotype in patients with optic neuritis (ON) without multiple sclerosis (MS), patients with optic neuritis (ON), and multiple sclerosis (MS), and control groups.
| Gene Marker | Genotype/Allele | Control Group n (%)(n = 318) | ON Group without MS (%)(n = 36) | p | Control Group n (%) (n = 318) | ON Group with MSn (%) (n = 26) | p |
|---|---|---|---|---|---|---|---|
| MMP-2(-1306 C/T)rs243865 | Genotype | 190 (59.75) | 190 (59.75) | 19 (73.10) | |||
| C/C | 108 (33.96) | 25 (69.40) | 0.23 | 108 (33.96) | 7 (26.90) | 0.26 | |
| C/T | 20 (6.29) | 11 (30.60) | 7 | 20 (6.29) | 0 (0.00) | 0 | |
| T/T | 318 (100.00) | 0 (0.00) | 318 (100.00) | 26 (100.00) | |||
| Total | 36 (100.00) | ||||||
| Allele | 488 (76.70) | 488 (76.70) | 45 (86.54) | ||||
| C | 148 (23.30) | 61 (84.70) | 0.12 | 148 (23.30) | 7 (13.46) | 0.10 | |
| T | 11 (15.30) | 3 | 4 |
MMP—matrix metalloproteinase, p value—significance level (alfa = 0.05), p-value HWE—significance level (alfa = 0.05) by Hardy-Weinberg equilibrium.