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. 2018 Jul 3;11:3793–3803. doi: 10.2147/OTT.S165220

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© 2018 Yao et al. This work is published and licensed by Dove Medical Press Limited

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Limonin inhibited HCC cell proliferation and colony formation.

Notes: (A) Chemical structure of limonin, (B and C) limonin inhibited HCC cell proliferation. Hep3B (B) or HepG2 (C) cells were incubated with various concentrations of limonin for different times, and the cell viability was determined. (D and E) Limonin suppressed HCC cell anchorage-independent growth in soft agar. Hep3B (D) or HepG2 (E) cell suspensions were plated into a 6-well plate and exposed to different limonin concentrations; the anchorage-independent assay was performed. The asterisks (*p<0.05, **p<0.01, ***p<0.001, Student’s t-test) indicate significant difference versus the control.

Abbreviation: HCC, hepatocellular carcinoma.