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. 2018 Jul 3;11:3793–3803. doi: 10.2147/OTT.S165220

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© 2018 Yao et al. This work is published and licensed by Dove Medical Press Limited

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Limonin suppressed Akt activity in HepG2 cells.

Notes: (A) Limonin inhibited Akt activity and its downstream signaling pathway. The cell lysates of HepG2 cells treated with limonin were probed with indicated antibodies. (B) Limonin blocked Akt activity in mitochondria. The mitochondrial fractions were isolated, and Akt phosphorylation was determined. (C) Limonin inhibited Akt-mediated HK-2 phosphorylation. The lysates of the mitochondria fractions were immunoprecipitated with HK-2 antibody and phosphor-Akt was examined.

Abbreviation: HK-2, hexokinase-2.