Table 1.
Study population: clinical characteristics in AMI octogenarians
| Characteristics, n (%) | Control group (n=93) | UAP group (n=564) | AMI group (n=135) | P-value |
|---|---|---|---|---|
| General conditions | ||||
| Age (years) | 81.63±2.04 | 81.95±2.04 | 82.71±2.48 | 0.043 |
| Male | 60 (64.5) | 402 (71.3) | 99 (73.3) | 0.323 |
| HR (bpm) | 71.09±11.71 | 73.27±12.93 | 80.88±17.58##,** | 0.000 |
| BMI (kg/m2) | 24.31±3.75 | 24.74±3.37 | 24.67±3.23 | 0.527 |
| SBP (mmHg) | 139.29±20.52 | 139.48±20.25 | 126.39±22.32##,** | 0.000 |
| DBP (mmHg) | 72.91±11.77 | 72.23±11.78 | 68.94±12.22#,** | 0.009 |
| EF (%) | 60.33±6.95 | 56.67±9.26∆∆ | 50.22±10.05##,** | 0.000 |
| Risk factors | ||||
| Hypertension | 76 (81.7) | 443 (78.5) | 95 (70.4) | 0.073 |
| DM | 22 (23.7) | 195 (34.6) | 46 (34.1) | 0.114 |
| Hyperlipidemia | 23 (24.7) | 135 (23.9) | 20 (14.8) | 0.064 |
| Previous MI | 8 (8.6) | 113 (20.0)∆∆ | 16 (11.9)** | 0.005 |
| Previous stroke | 12 (12.9) | 121 (21.5) | 25 (18.5) | 0.145 |
| CRF | 7 (7.5) | 60 (10.6) | 19 (14.1) | 0.281 |
| Smoking | 15 (16.1) | 137 (24.3) | 33 (24.4) | 0.215 |
| Baseline blood feature | ||||
| TC (mmol/L) | 3.85±0.89 | 3.94±1.12 | 4.01±1.13 | 0.057 |
| TG (mmol/L) | 1.33±1.12 | 1.38±0.97 | 1.31±0.77 | 0.707 |
| HDL-C (mmol/L) | 1.28±0.42 | 1.24±0.34 | 1.23±0.53 | 0.598 |
| LDL-C (mmol/L) | 2.12±0.73 | 2.28±0.83 | 2.32±0.87 | 0.163 |
| FBG (mmol/L) | 5.85±1.69 | 6.75±4.39 | 8.85±4.51##,** | 0.000 |
| UA (μmol/L) | 344.2±98.52 | 347.1±104.6 | 392.4±107.4##,** | 0.000 |
| eGFR (mL/min/1.73 m2) | 80.37±49.52 | 76.49±41.15 | 66.52±19.67##,** | 0.013 |
| Cys C (mg/L) | 1.56±0.62 | 1.62±0.84 | 1.96±0.81##,** | 0.000 |
| Hcy (nmol/L) | 15.12±7.58 | 16.27±8.18 | 18.14±7.33##,** | 0.012 |
| Cardiovascular medication | ||||
| Aspirin | 84 (90.3) | 545 (96.6)∆∆ | 132 (97.8)** | 0.007 |
| Clopidogrel | 75 (80.6) | 534 (94.7)∆∆ | 132 (97.8)** | 0.000 |
| Beta-blocker | 51 (54.8) | 360 (63.8) | 86 (63.7) | 0.244 |
| ACEI/ARB | 58 (62.4) | 299 (53.0) | 82 (60.7) | 0.096 |
| Statin | 81 (87.1) | 518 (91.8) | 128 (94.8) | 0.113 |
Notes: Data are shown as mean ± SD or n (%). Con versus UAP group
P<0.01; Con versus AMI group
P<0.05,
P<0.01; UAP versus AMI group
P<0.01. Bold figures indicate significant difference (P<0.05).
Abbreviations: ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; AMI, acute myocardial infarction; BMI, body mass index; Con, control; CRF, chronic renal failure; Cys C, cystatin C; DBP, diastolic blood pressure; DM, diabetes mellitus; EF, ejection fraction; eGFR, estimated glomerular filtration rate; FBG, fasting blood glucose; Hcy, homocysteine; HDL-C, high density lipoprotein-C; HR, heart rate; LDL-C, low density lipoprotein-C; MI, myocardial infarction; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; UA, uric acid; UAP, unstable angina pectoris; Con, control.