Table 2. Characteristics of Study Participants According to History of Deliriuma.
| Characteristic | No Delirium (n = 708)b |
Delirium (n = 279)b |
P Valuec |
|---|---|---|---|
| Follow-up, median (IQR), y | 4.3 (2.0-7.1) | 4.7 (2.5-7.8) | NA |
| No. of assessments in last 6 y, median (IQR)d | 2 (1-3) | 3 (2-4) | NA |
| Study | |||
| Vantaa 85+ (n = 290) | 232 (80.0) | 58 (20.0) | NA |
| CC75C (n = 241) | 142 (58.9) | 99 (41.1) | |
| CFAS (n = 456) | 334 (73.2) | 122 (26.8) | |
| Age at death, mean (SD), y | 89 (6.7) | 90 (5.8) | .03 |
| Female | 472 (66.7) | 210 (75.3) | <.001 |
| Years of education, median (IQR) | 9 (6-13) | 9 (8-14) | <.001 |
| Pathologic findinge | |||
| Braak stage (n = 978) | 346 (50.6) | 166 (56.5) | .09 |
| Neocortical amyloid plaques (n = 960) | 344 (49.7) | 138 (51.5) | .62 |
| Vascular (infarcts, lacunes, or hemorrhages) (n = 884) | 358 (55.6) | 139 (57.9) | .54 |
| Lewy bodies in substantia nigra (n = 967) | 67 (9.7) | 27 (9.7) | .99 |
| Pathologic burden scoref | |||
| 0 | 132 (18.6) | 40 (14.3) | .10 |
| 1 | 207 (29.2) | 72 (25.8) | |
| 2 | 220 (31.1) | 107 (38.4) | |
| 3 or 4 | 149 (21.0) | 60 (21.5) | |
| Any moderate to severe pathologic burdeng | 576 (81.4) | 239 (85.7) | .20 |
Abbreviations: CC75C, Cambridge City Over-75s Cohort; CFAS Cognitive Function and Ageing Study; IQR, interquartile range; NA, not applicable.
Data are presented as number (percentage) of patients unless otherwise indicated.
Delirium means evidence of delirium at any time compared with those with no history of delirium.
P values for differences in means and medians (continuous measures) were obtained by 2-sample t test or Wilcoxon test, and proportions were tested using χ2 tests.
Six years is the chosen intercept for this model describing the final trajectory of cognitive decline.
Pathologic measures are dichotomized. Numbers given here are for the higher category (Braak stage ranges from 0 to 6); figures are those scoring 4, 5, or 6. Neocortical amyloid plaques scored as none, mild, moderate, or severe; figures are those scoring moderate to severe. Vascular indicates the presence (yes/no) of infarcts in arteries larger than 10 mm, lacunar lesions, or hemorrhage. Lewy bodies scored as none, mild, moderate, or severe; figures are those scoring moderate to severe. Full details are given in the eAppendix in the Supplement.
Pathologic burden score refers to the number of pathologic measures in a higher category for an individual.
Any moderate to severe pathologic findings were scored as a pathologic burden score of 1 or higher.