. Author manuscript; available in PMC: 2018 Oct 6.

Published in final edited form as: Kidney Blood Press Res. 2018 Apr 6;43(2):555–567. doi: 10.1159/000488829

Table 4.

Logistic Regression Models of Visit 3 kidney disease^*: MetS Severity vs. ATP-III MetS^**

	Overall Odds Ratio of Visit 3 Kidney Disease		Sex-Specific Odds Ratios of Visit 3 Kidney Disease

	Odds Ratio (95% CI)	p-value	Male Odds Ratio (95% CI)	p-value	Female Odds Ratio (95% CI)	p-value
Outcome: Incident CKD at Visit 3
Model with Visit 1 MetS Severity (Quartiles)
25–50^th	1.58 (0.90, 2.79)	0.1124	2.01 (0.85, 4.77)	0.1134	1.31 (0.61, 2.78)	0.4903
50–75^th	1.88 (1.09, 3.25)	0.0231	1.98 (0.85, 4.61)	0.1126	1.81 (0.89, 3.72)	0.1036
> 75^th	1.07 (0.99, 3.50)	0.0556	0.63 (0.17, 2.34)	0.4876	2.47 (1.13, 5.37)	0.0229
Linear trend p-value	0.1227		0.4933		*0.0128*
			Interaction p-value = 0.0645
Model with ATP-III MetS			Odds Ratio (95% CI)		p-value

Visit 1 ATP-III MetS	1.30 (0.93, 1.84)	0.1289	1.07 (0.60, 1.92)	0.8111	1.45 (0.95, 2.22)	0.0878
			Interaction p-value = 0.4153

Outcome: Rapid Decline of eGFR (Visit 1 to Visit 3 > −16.8% of Visit 1)
Model with Visit 1 MetS Severity (Quartiles)
25–50^th	0.97 (0.75, 1.26)	0.8072	0.87 (0.57, 1.32)	0.5047	1.03 (0.74, 1.43)	0.8795
50–75^th	0.96 (0.74, 1.24)	0.7354	0.64 (0.42, 0.99)	0.0444	1.20 (0.86, 1.67)	0.2768
> 75^th	1.03 (0.76, 1.41)	0.8310	0.75 (0.43, 1.30)	0.2999	1.22 (0.84, 1.79)	0.2947
Linear trend p-value	0.8568		0.6939		0.2023
			Interaction p-value = 0.0862
Model with ATP-III MetS			Odds Ratio (95% CI)		p-value

Visit 1 ATP-III MetS	1.06 (0.86, 1.29)	0.5919	0.97 (0.68, 1.39)	0.8846	1.10 (0.86, 1.40)	0.4521
			Interaction p-value = 0.5853

Two outcomes were utilized: CKD at Visit 3, and Rapid Decline of eGFR (Visit 1 to Visit 3 > −16.8 percent of Visit 1).

^**

For each of the two outcomes, four models were fit. Two models across all subjects were fit, one with Visit 1 MetS severity and one with ATP-III MetS (first set of columns, divided between incident CKD as an outcome in the upper half of table and rapid eGFR decline in the bottom half of table). These models then were re-fit to include an interaction with sex to allow for sex-specific examination of the association between MetS and Low Visit 1 GFR. For all eight models, the following covariates were included: Visit 1 age, Visit 1 eGFR, sex, physical activity, nutrition, and current smoking status. Differences in income were observed between males and females, but income was not found to be a confounder (i.e., did not change above estimates) and was thus removed from the models given large amounts of missing data on this variable.

^**

Reference category: < 25^th percentile.