Extended Data Figure 7. Comparing human YFV-specific effector and memory CD8 T cell signatures with mouse effector and memory CD8 T cells.

The RNA-seq data from YFV-tetramer⁺ effector and long-term memory CD8 T cells was compared with published mouse transcriptional profiles. The datasets used were from Kaech et al., 2002²⁵ (1); Doering et al., 2012²⁶ (2); Wherry²⁷ et al., 2007 (3); Wirth²⁸ et al., 2010 (4); and Sarkar²⁹ et al., 2008 (5). a, Enrichment plots show the proportion of genes in the leading edge; the colour of the plots shows the normalized enrichment score. The size of the circles represents the number of genes in the mouse signatures that are present in the leading edge of the enrichment plots. b, The GSEA leading edge analysis tool was used to identify genes that were commonly correlated to the effector or memory phenotype and that overlapped with genes in the corresponding mouse signatures.