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. 2018 Jul 9;13(7):e0200069. doi: 10.1371/journal.pone.0200069

Table 3. Functional annotation clustering of genes in regions with high ROH accumulation.

Cluster 1 Enrichment Score: 8.96
Category Term P Value Genes Fold Enrichment
INTERPRO Propeptide, peptidase A1 (IPR012848) 2.45E-13 PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG19, PAG20, 14.36
PAG21, LOC504812, LOC614287, MGC157405, MGC157408
INTERPRO Peptidase A1 (IPR001461) 1.35E-12 PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG19, PAG20, 13.02
PAG21, LOC504812, LOC614287, MGC157405, MGC157408
INTERPRO Aspartic peptidase (IPR021109) 1.48E-11 PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG19, PAG20, 11.26
PAG21, LOC504812, LOC614287, MGC157405, MGC157408
GOTERM_MF_DIRECT Aspartic-type endopeptidase activity (GO:0004190) 1.22E-10 PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG19, PAG20, 9.76
PAG21, LOC504812, LOC614287, MGC157405, MGC157408
INTERPRO Peptidase aspartic, active site (IPR001969) 2.00E-10 PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG20, 12.03
PAG21, LOC504812, LOC614287, MGC157405
UP_KEYWORDS Aspartyl protease 2.08E-10 PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG20, 12.00
PAG21, LOC504812, LOC614287, MGC157405
GOTERM_BP_DIRECT Protein catabolic process (GO:0030163) 2.15E-09 PAG1, PAG4, PAG7, PAG15, PAG16, PAG17, PAG18, PAG20, 8.97
PAG21, LOC504812, LOC614287, MGC157405
GOTERM_BP_DIRECT Proteolysis (GO:0006508) 0.0002 GGH, PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, PAG20, 2.83
PAG21, LOC504812, LOC614287, MGC157405, PROZ, TPP2
UP_KEYWORDS Protease 0.0002 CASP8, CLPP, CTSB, CTSC, CTSZ, ECE2, F7, F10, PAG1, PAG4, PAG5, PAG7, PAG15, PAG16, PAG17, PAG18, 2.27
      PAG19, PAG20, PAG21, PARL, NPEPL1, USP4, USP14, TPP2, LOC504812, LOC614287, MGC157405  
Cluster 2 Enrichment Score: 2.03
Category Term P Value Genes Fold Enrichment
SMART DEFSN (SM00048) 0.0005 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD 12.18
INTERPRO Beta defensin/Neutrophil defensin (IPR006080) 0.0006 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD 11.57
INTERPRO Beta defensin type (IPR001855) 0.0012 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD 9.92
UP_KEYWORDS Defensin 0.0061 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD 6.59
UP_KEYWORDS Antibiotic 0.0204 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD, PENK 3.78
UP_KEYWORDS Antimicrobial 0.0445 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD, PENK 3.08
GOTERM_BP_DIRECT Defense response to bacterium (GO:0042742) 0.073291513 DEFB1, DEFB4A, DEFB5B, DEFB10, EBD, NOS2, PENK 2.38
Annotation Cluster 3 Enrichment Score: 1.54
Category Term P Value Genes Fold Enrichment
UP_KEYWORDS Microtubule 0.0052 AURKA, DYNLL2, DYNLRB2, HAUS1, KATNAL2, KIF20A, NDRG1, REEP4, SKA1, 2.68
TUBB1, TUBB4A, TUBGCP3
UP_KEYWORDS Cytoskeleton 0.0485 AURKA, CETN1, CETNNA1, DAG1, DMTN, DYNLL2, DYNLRB2, FAM110B, FER, HAUS1, KATNAL2, 1.55
KIF20A, MAP6D1, NDRG1, PDLIM2, PPP2CA, REEP4, RHOA, ROCK1, SKA1, TUBB1, TUBB4A, TUBGCP3
GOTERM_CC_DIRECT Microtubule (GO:0005874) 0.0968 DYNLL2, DYNLRB2, HAUS1, KATNAL2, KIF20A, NDRG1, REEP4, SKA1, MAP6D1 1.83
      TUBB1, TUBB4A