Fig 2. The best two-biomarker panel, combining H-FABP and GFAP, at correctly classifying mTBI CT-positive and CT-negative patients compared to the individual best-performing protein: H-FABP.

Performance was investigated at 100% sensitivity, and the panel’s specificity reached 46% (dot, cut-off: 2 parameters, black), compared to the best-performing single marker, H-FABP, which reached 32% specificity (triangle, cut-off: 1.99 ng/mL, grey).