Table 4.
Daytime sleepiness from baseline to week 18 in advanced PD patients with sleep disturbances
| Subgroup | PPX SR | PPX IR | ||
|---|---|---|---|---|
| Baseline | 18 weeks | Baseline | 18 weeks | |
| ESS, n | 42 | 56 | ||
| Total scorea | 7.9±3.9 | 8.9±4.6 | 8.9±4.5 | 9.5±5.3 |
| Adjustedb mean changea | −0.8 | −0.1 | ||
| SR versus IR, P-value (95% CI) | −0.6, P=0.4573 (−2.4 to 1.1) | |||
| PDSS item 15, n | 52 | 51 | ||
| Total scorec | 3.2±1.7 | 6.3±3.0 | 3.2±1.7 | 5.8±3.2 |
| Adjustedb mean changea | 3.4 | 2.9 | ||
| SR versus IR, P-value (95% CI) | 0.5, P=0.4161 (−0.7 to 1.7) | |||
Notes:
a
Negative change implies improvement;
b
adjusted = Least-square means adjusted for pooled country and baseline scores;
c
positive change implies improvement. Data are presented as mean ± SD.
Abbreviations: ESS, Epworth Sleepiness Scale; IR, immediate release; PD, Parkinson’s disease; PDSS, Parkinson’s Disease Sleep Scale; PPX, pramipexole; SR, sustained release.