Table 4.
Associations between Metabolomic Signature and Mortality in 103 Patients with Cirrhosis in Univariate Cox Regression Models
| Metabolites | Hazard Ratio | P Value | Q Value | Super Pathway | Sub Pathway |
|---|---|---|---|---|---|
| MELD-Na Score | 1.16 | <0.0001 | 0.0035 | ||
| glucuronate | 2.34 | 0.0004 | 0.0070 | Carbohydrate | Aminosugar Metabolism |
| 3-ureidopropionate | 2.45 | 0.0015 | 0.0158 | Nucleotide | Pyrimidine Metabolism, Uracil containing |
| S-adenosylhomocysteine | 2.73 | 0.0018 | 0.0158 | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism |
| trans-aconitate | 2.08 | 0.0025 | 0.0175 | Energy | TCA Cycle |
| 3-(4-hydroxyphenyl)lactate | 2.63 | 0.0032 | 0.0187 | Amino Acid | Phenylalanine and Tyrosine Metabolism |
| arabitol/xylitol | 2.42 | 0.0080 | 0.0400 | Carbohydrate | Pentose Metabolism |
| 3-methoxytyramine sulfate | 2.13 | 0.0155 | 0.0649 | Amino Acid | Phenylalanine and Tyrosine Metabolism |
| phenyllactate | 1.56 | 0.0167 | 0.0649 | Amino Acid | Phenylalanine and Tyrosine Metabolism |
| N-formylmethionine | 3.00 | 0.0253 | 0.0886 | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism |
| erythronate | 2.05 | 0.0447 | 0.1215 | Carbohydrate | Aminosugar Metabolism |
| 4-acetamidobutanoate | 1.62 | 0.0465 | 0.1215 | Amino Acid | Polyamine Metabolism |
| adenosine | 2.17 | 0.0472 | 0.1215 | Nucleotide | Purine Metabolism, Adenine containing |
| 7-methylguanine | 2.66 | 0.0486 | 0.1215 | Nucleotide | Purine Metabolism, Guanine containing |
| N-acetylputrescine | 1.97 | 0.0592 | 0.1310 | Amino Acid | Polyamine Metabolism |
| N6-carbamoylthreonyladenosine | 1.99 | 0.0613 | 0.1310 | Nucleotide | Purine Metabolism, Adenine containing |
| adenine | 2.18 | 0.0672 | 0.1310 | Nucleotide | Purine Metabolism, Adenine containing |
| N-acetylserine | 1.95 | 0.0682 | 0.1310 | Amino Acid | Glycine, Serine and Threonine Metabolism |
| N2,N2-dimethylguanosine | 2.12 | 0.0711 | 0.1310 | Nucleotide | Purine Metabolism, Guanine containing |
| creatinine | 3.24 | 0.1027 | 0.1797 | Amino Acid | Creatine Metabolism |
| cytidine | 1.45 | 0.1471 | 0.2351 | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism |
| N1-methyladenosine | 3.05 | 0.1504 | 0.2351 | Nucleotide | Purine Metabolism, Adenine containing |
| pseudouridine | 1.80 | 0.1545 | 0.2351 | Nucleotide | Pyrimidine Metabolism, Uracil containing |
| myo-inositol | 1.49 | 0.1727 | 0.2519 | Lipid | Inositol Metabolism |
| gamma-glutamylphenylalanine | 1.74 | 0.1940 | 0.2714 | Peptide | Gamma-glutamyl Amino Acid |
| N4-acetylcytidine | 1.33 | 0.2016 | 0.2714 | Nucleotide | Pyrimidine Metabolism, Cytidine containing |
| picolinate | 1.46 | 0.2400 | 0.3111 | Amino Acid | Tryptophan Metabolism |
| dimethylarginine (SDMA + ADMA) | 2.02 | 0.2562 | 0.3203 | Amino Acid | Urea cycle; Arginine and Proline Metabolism |
| N-acetylalanine | 1.68 | 0.2926 | 0.3470 | Amino Acid | Alanine and Aspartate Metabolism |
| N-acetylvaline | 1.74 | 0.2974 | 0.3470 | Amino Acid | Leucine, Isoleucine and Valine Metabolism |
| C-glycosyltryptophan | 1.27 | 0.4804 | 0.5424 | Amino Acid | Tryptophan Metabolism |
| cystathionine | 1.17 | 0.5012 | 0.5482 | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism |
| N6-acetyllysine | 1.43 | 0.5508 | 0.5842 | Amino Acid | Lysine Metabolism |
| 3-methoxytyrosine | 0.76 | 0.5928 | 0.6102 | Amino Acid | Phenylalanine and Tyrosine Metabolism |
| 1-methylhistidine | 1.01 | 0.9740 | 0.9740 | Amino Acid | Histidine Metabolism |
Log transformed values of metabolites were used in the Cox proportional hazards regression models. Patients were censored at the time of last follow-up or liver transplantation. For calculation of Q-values, P-values < 0.0001 were considered as 0.0001.
The metabolites in this table were first sorted by their P-value and then Q-values were determined. The Q-value assigns the false discovery rate for the selected list of metabolites. Twenty-two of the metabolites are significantly associated with mortality at the Q-value level of 25%.