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. 2018 May-Jun;9(3):157–166. doi: 10.29252/nirp.bcn.9.3.157

Figure 1.

Figure 1

A) Experimental protocols for METH-induced reinstatement of conditioned place preference (CPP) in the rats. B) In the set of experiments, 24 hours after the last day of the extinction period, the animals were placed in the CPP box and tested for CPP test by only injection of the priming dose of METH (0.25 mg/kg; SC). C) In the set of experiments (ineffective METH dose + acute restraint stress-induced reinstatement), after extinction was established, the rats were given a 3-h restraint stress period and after 60 min, they were placed in the CPP box and tested for reinstatement by only injection of the ineffective dose of METH (0.125 mg/kg; SC). D) In the set of experiments, after the CPP acquisition, 60 min before animals placing into the CPP box, they received 1 hour restraint stress as a chronic stress period every day in the extinction period, 24 hours after the last day of the extinction period. The animals were tested for reinstatement by only injection of the ineffective dose of METH (0.125 mg/kg; SC).