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. 2018 May-Jun;9(3):157–166. doi: 10.29252/nirp.bcn.9.3.157

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Copyright© 2018 Iranian Neuroscience Society

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dose–response effects of METH on the reinstating of extinguished METH-induced conditioned place preference

In the right panel, animals received METH (0.5 mg/kg; SC) during conditioning phase, tp (5)=8.598 (P<0.001). The day after postconditioning day, the animals were given free accesses to both chambers for 8 days. To assess the METH-induced reinstatement, the animals received ineffective doses of METH, i.e., 0.125 and 0. 25 mg/kg and saline as a control group. Each column represents the Mean±SEM parameter values of 6 rats; *** P<0.001 compared with the pretest day; † P<0.01, †† P<0.001 and ††† P<0.0001 different from the posttest day; ++ P<0.01 compared with the last day of extinction period.