Figure 1.

Percentages of responders patients for pneumococcal vaccine at 4, 12 and 24 months after immunization in ELISA (white) and in OPA (black). Note: Responders patients for each serotype at a specific time point were defined as a two-fold increase of IgG anti-PS compared to baseline by ELISA (in white) and a titer four-fold increase from baseline of Ig anti-PS by OPA (in black) for each serotype. Patients were assigned as responders when more than 70% of serotypes tested fit with those criteria.