Table 1.

Geometric mean (95% CI) Concentrations by ELISA of IgG Antibody at baseline, 4, 12 and 24 months after immunization.

Serotypes		Baseline	M4	M12	M24
4	NR	0.6 (0.4–0.9)	0.9 (0.5–1.4)	0.7 (0.4–1.2)	0.7 (0.3–1.6)
	R	0.6 (0.3–1.3)	1.8$ (1–3.4)	1.2 (0.6–2.3)	1.8 (0.7–4.3)
6B	NR	1.6 (0.8–3.1)	2 (1.1–3.8)	1.6 (0.8–3.3)	2.0 (0.8–4.6)
	R	1.9 (0.7–5.4)	6.6 (2.3–18.3)	3.7 (1.3–10.1)	3.7 (1.0–14.4)
9V	NR	1.1 (0.6–2.2)	1.7 (0.9–3.2)	1.5 (0.8–2.9)	1.6 (0.6–4.5)
	R	2.6 (0.9–7.3)	6.5# (2.5–17.2)	3.6 (1.1–11.8)	2.9 (0.5–16.3)
14	NR	6.3 (2.7–15)	10 (4.5–22.1)	8.7 (3.3–22.4)	6.9 (1.7–28.2)
	R	4.4 (1.5–13)	9.9 (3.7–26.6)	8.4 (3.-22.6)	8.2 (3.2–21.4)
18C	NR	1.2 (0.7–2.1)	2.1 (1.3–3.4)	1.6 (0.9–2.9)	1.8 (0.6–5.2)
	R	3.2# (1.4–7.3)	9.4# (3.9–23)	6.3# (2.6–14.9)	2.6 (0.6–15.3)
19F	NR	1.7 (0.9–3.1)	2.3 (1.5–3.5)	2 (1.1–3.6)	3.1 (1.1–8.2)
	R	3.5 (1.7–7.3)	12.8$,# (3.9–41.3)	8.2# (2.7–24.7)	2.5 (0.6–10.6)
23F	NR	1.3 (0.6–3)	1.6 (0.7–3.5)	1.2 (0.5–2.9)	1.2 (0.4–3.3)
	R	1.1 (0.4–3.4)	3.7 (1.1–13)	2.5 (0.8–7.7)	1.2 (0.2–5.6)
10A	NR	1.2 (0.3–4.9)	1.7 (0.4–7.4)	1.7 (0.4–7.1)	2.0 (0.7–534)
	R	1.4 (0.6–3.2)	6.7$,# (2.4–18.9)	3.9 (1.4–10.4)	6.2 (1.1–35.9)
12F	NR	0.4 (0.1–1.3))	0.5 (0.1–1.9)	0.6 (0.2–1.7)	0.6 (0.2–2.1)
	R	0.6 (0.3–1.1)	2.1 (0.7–6.2)	1.4 (0.5–3.9)	1.0 (0.4–2.6)
15B	NR	2.8 (0.5–15.9)	3.3 (0.5–20.1)	3.1 (0.5–19.5)	3.5 (0.7–18.1)
	R	4 (1.5–10.4)	11.3 (3.4–38.1)	8 (2.5–25.7)	5.6 (1.0–32.4)

Note: Responders at four month were defined as at least an IgG- two fold increased from baseline by ELISA. Data are in geometric means: antibody concentrations are in µg/ml (95% confidence limits). R: Reponders group, NR: Non-reponders group,

^$p<0.05 vs. baseline