Appendix Table 1.

Chinese epidemiological data associated with pneumococcal disease 1.

Pneumococcal Disease	0 – 2 year	3 – 5 year	5 – 17 year	18 – 34 year	35 – 49 year	50 – 64 year	over 65 year
CAP
Annual incidence (per 10,0000)	17695(5013 – 30377)	23082.5(2174 – 43991)	7229.5(227 – 14232)	1309(109 – 2509)	605.5(159 – 1052)	1139(159 – 2119)	5325(2165 – 8485)
Proportion of hospitalization	0.072(0.034 – 0.109)	0.064(0.019 – 0.109)	0.029(0.013 – 0.045)	0.088(0.01 – 0.166)	0.172(0.027 – 0.317)	0.214(0.05 – 0.378)	0.377(0.084 – 0.67)
Case-fatality of hospitalized CAP	0.021(0.002 – 0.04)	0.021(0.002 – 0.04)	0.003(0.002 – 0.003)	0.004(0.001 – 0.007)	0.025(0.017 – 0.032)	0.031(0.025 – 0.037)	0.058(0.052 – 0.063)
IPD
Annual incidence (per 10,0000)	13.9(9.8 – 18)	14.2(12.8 – 15.6)	1.1(1 – 1.2)	1.1(1 – 1.2)	1.1(1 – 1.2)	1.1(1 – 1.2)	10(9.8 – 10.2)
Proportion of meningitis in IPD	0.28(0.21 – 0.35)	0.12(0.09 – 0.15)	0.33(0.25 – 0.42)	0.18(0.14 – 0.23)	0.1(0.08 – 0.13)	0.09(0.07 – 0.11)	0.02(0.02 – 0.03)
Case-fatality of meningitis	0.19(0.05 – 0.33)	0.19(0.05 – 0.33)	0.07(0.05 – 0.1)	0.14(0.1 – 0.18)	0.14(0.11 – 0.18)	0.14(0.11 – 0.18)	0.29(0.24 – 0.35)
Case-fatality of bacteremia	0.14(0.05 – 0.23)	0.14(0.05 – 0.23)	0.14(0.05 – 0.23)	0.15(0.13 – 0.18)	0.15(0.13 – 0.18)	0.15(0.13 – 0.18)	0.24(0.13 – 0.35)
AOM
Annual incidence(per 10,0000)	19707(16930 – 22485)	15488(14355 – 16620)	—	—	—	—	—
Complex AOM	0.104(0.104 – 0.104)	0.11(0.11 – 0.11)	—	—	—	—	—
CAP: community-acquired pneumonia; AOM: acute otitis media; IPD: invasive pneumococcal disease.