Table 2.
Serotype distribution and vaccine-serotype coverage of the pneumococci isolated from 2000 to 2016 in mainland China.
| Strains | Serotype /Serogroup | Number (n) | Proportion (%) | 95% CI | I2(%) a | P b |
|---|---|---|---|---|---|---|
| Strains from children<18y (N = 11,711) | ||||||
| 19F | 3487 | 29.8 | 28.3–30.0 | / | / | |
| 19A | 1192 | 10.2 | 9.3–10.4 | / | / | |
| 23F | 1089 | 9.3 | 8.6–9.7 | / | / | |
| 14 | 859 | 7.3 | 7.9–8.9 | / | / | |
| 6B | 581 | 5.0 | 6.8–7.7 | / | / | |
| 6A | 500 | 4.3 | 3.9–4.6 | / | / | |
| 19 | 446 | 3.8 | 3.5–4.2 | / | / | |
| 23 | 280 | 2.4 | 2.1–2.7 | / | / | |
| 6 | 277 | 2.4 | 2.1–2.6 | / | / | |
| 15 | 207 | 1.8 | 1.5–2.0 | / | / | |
| PCV10 | / | 52.3 | 44.3–60.3 | 99.1 | <0.001 | |
| PCV13 | / | 68.4 | 60.8–76. | 99.5 | <0.001 | |
| PPSV23 | / | 65.5 | 58.0–73.0 | 99.4 | <0.001 | |
| Strains from adults≥18y (N = 1,963) | ||||||
| 19 | 248 | 12.6 | 11.2–14.1 | / | / | |
| 3 | 242 | 12.3 | 10.9–13.8 | / | / | |
| 6 | 178 | 9.1 | 7.8–10.3 | / | / | |
| 19F | 172 | 8.8 | 7.5–10.0 | / | / | |
| 23 | 146 | 7.4 | 6.3–8.6 | / | / | |
| 19A | 122 | 6.2 | 5.1–7.3 | / | / | |
| 14 | 106 | 5.4 | 4.4–6.4 | / | / | |
| 23F | 71 | 3.6 | 2.8–4.4 | / | / | |
| 15 | 52 | 2.6 | 1.9–3.4 | / | / | |
| 17 | 25 | 1.3 | 0.8–1.8 | / | / | |
| PCV10 | / | 29.7 | 19.2–40.3 | 97.0 | <0.001 | |
| PCV13 | / | 49.5 | 32.6–66.3 | 98.6 | <0.001 | |
| PPSV23 | / | 50.7 | 34.6–66.9 | 98.3 | <0.001 | |
| Invasive strains (N = 896) | ||||||
| 19F | 210 | 23.5 | 20.6–26.3 | / | / | |
| 19A | 201 | 22.2 | 19.4–25.0 | / | / | |
| 14 | 146 | 16.4 | 13.9–18.9 | / | / | |
| 23F | 59 | 6.7 | 5.0–8.4 | / | / | |
| 6B | 44 | 5.1 | 3.6–6.6 | / | / | |
| 9V | 32 | 3.6 | 2.4–4.8 | / | / | |
| 1 | 17 | 1.9 | 1.0–2.8 | / | / | |
| 8 | 15 | 1.7 | 0.8–2.5 | / | / | |
| 7F | 13 | 1.5 | 0.7–2.2 | / | / | |
| 5 | 10 | 1.1 | 0.4–1.8 | / | / | |
| PCV10 | / | 61.4 | 55.2–67.7 | 70.6 | <0.001 | |
| PCV13 | / | 87.4 | 82.7–92.0 | 79.4 | <0.001 | |
| PPSV23 | / | 86.9 | 81.7–92.2 | 84.6 | <0.001 | |
| Non-invasive strains (N = 7,577) | ||||||
| 19F | 2,006 | 26.5 | 25.5–27.5 | / | / | |
| 19A | 637 | 8.4 | 7.8–9.0 | / | / | |
| 23F | 600 | 7.9 | 7.3–8.5 | / | / | |
| 14 | 499 | 6.6 | 6.0–7.1 | / | / | |
| 19 | 439 | 5.8 | 5.3–6.3 | / | / | |
| 6A | 371 | 4.9 | 4.4–5.4 | / | / | |
| 6B | 350 | 4.6 | 4.1–5.1 | / | / | |
| 23 | 299 | 3.9 | 3.5–4.4 | / | / | |
| 6 | 241 | 3.2 | 2.8–3.6 | / | / | |
| 15 | 171 | 2.3 | 1.9–2.6 | / | / | |
| PCV10 | / | 43.2 | 33.2–53.2 | 99.4 | <0.001 | |
| PCV13 | / | 55.7 | 43.5–67.8 | 99.7 | <0.001 | |
| PPSV23 | / | 53.4 | 41.5–65.3 | 99.7 | <0.001 | |
| Strains from the south of China(N = 9,442) | ||||||
| 19F | 2452 | 26.0 | 25.1 -26.9 | / | / | |
| 19A | 852 | 9.0 | 8.4 -9.6 | / | / | |
| 23F | 811 | 8.6 | 8.0 -9.2 | / | / | |
| 19 | 747 | 7.9 | 7.4–8.5 | / | / | |
| 14 | 609 | 6.4 | 6.0–6.9 | / | / | |
| 6B | 452 | 4.8 | 4.4–5.2 | / | / | |
| 6 | 382 | 4.0 | 3.6–4.4 | / | / | |
| 6A | 348 | 3.7 | 3.3–4.1 | / | / | |
| 23 | 312 | 3.3 | 2.9–3.7 | / | / | |
| 3 | 237 | 2.5 | 2.2–2.8 | / | / | |
| PCV10 | / | 50.1 | 40.5–59.6 | 98.2 | <0.001 | |
| PCV13 | / | 64.5 | 54.8–74.2 | 99.3 | <0.001 | |
| PPSV23 | / | 62.8 | 53.2–72.4 | 98.7 | <0.001 | |
| Strains from the north of China (N = 3,608) | ||||||
| 19F | 508 | 14.1 | 12.9–15.2 | / | / | |
| 23F | 343 | 9.5 | 8.5–10.5 | / | / | |
| 19 | 289 | 8.0 | 7.1–8.9 | / | / | |
| 14 | 264 | 7.3 | 6.5–8.2 | / | / | |
| 6A | 233 | 6.5 | 5.7–7.3 | / | / | |
| 19A | 191 | 5.3 | 4.6–6.0 | / | / | |
| 23 | 143 | 4.0 | 3.3–4.6 | / | / | |
| 6 | 113 | 3.1 | 2.6–3.7 | / | / | |
| 6B | 105 | 2.9 | 2.4–3.5 | / | / | |
| 15 | 92 | 2.5 | 2.0–3.1 | / | / | |
| PCV10 | / | 36.3 | 26.7–45.9 | 98.2 | <0.001 | |
| PCV13 | / | 50.5 | 36.2–64.8 | 99.3 | <0.001 | |
| PPSV23 | / | 47.8 | 35.7–59.9 | 98.7 | <0.001 |
Notes:
a
I2 means the total variation across studies that were due to heterogeneity.
b
P: The Cochran chi-square (χ2) test of Heterogeneity. A P value of <0.05 was considered statistically significant.
/: Not applicable.