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. 2018 Jul;16(4):322–329. doi: 10.1370/afm.2271

Table 4.

Relative Association Between the Presence of Individual Conditions on Time to Developing Incident Multimorbidity Between 2002-2003 and 2012-2013: Complementary Log-Log Model

Condition HR (95% CI) P Value
Hypertension 1.00 [Reference]
Ischemic heart disease 1.27 (0.91-1.78) .162
Arrhythmia 1.55 (1.06-2.26)a .024a
Diabetes mellitus 1.06 (0.63-1.78) .839
COPD 2.32 (1.55-3.46)a <.001a
Asthma 1.33 (1.05-1.70)a <.019a
Arthritis (any) 0.98 (0.83-1.16) .819
Osteoporosis 1.32 (0.87-2.01) .185
Cancer (any) 1.19 (0.86-1.63) .295
Affective mental health condition (any) 0.97 (0.71-1.31) .831
Otherb 1.21 (0.64-2.30) .552

COPD = chronic obstructive pulmonary disease; HR = hazard ratio.

Note: From a sample of participants having 1 condition in 2002-2003 (n = 1,534), and an outcome of 1 or more incident conditions. Complementary log-log models are discrete time equivalent of Cox proportional hazards models for continuous time. This model adjusted for all baseline patient characteristics, and differential nonresponse using longitudinal sample weighting. HR >1.00 represents increased risk; an HR of <1.00 indicates reduced risk.

a

Conditions significantly more more likely than hypertension to be associated with incident multimorbidity.

b

Includes participants with conditions with low prevalence; congestive heart failure, stroke, psychotic mental health condition, and dementia/Alzheimer’s (Table 2). Combined, these individuals in the “other” category accounted for <1% of the sample.