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. 2018 Jul 9;12(4):044104. doi: 10.1063/1.5038965

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© 2018 Author(s).

1932-1058/2018/12(4)/044104/12

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FIG. 2. — Inertial focussing of particles and blood cells: mirrored equilibrium position as a function of mean flow velocity for 12, 8, and 2-μm-diameter particles (red) and blood components (green); WBCs, RBCs, and platelets (a). Heat maps showing the size-dependent velocity (b) and Re_p (c) regimes for efficient particle binning (focussing to flanking outlets, or exiting the central outlet without focussing), coupled with the velocity regime for blood cells (d). Efficient focussing occurs with ≥5-μm-diameter particles. T cells and other white blood cells are effectively separated at Ū ≥ 1 m/s, whereas red blood cells and platelets do not migrate to the flanking outlets. The impact of a deformation lift force directing cells towards the channel centre is evident at Ū 6 m/s with WBCs and at Ū > 2 m/s with RBCs.