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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Pediatr Crit Care Med. 2018 Jul;19(7):609–618. doi: 10.1097/PCC.0000000000001553

Figure 4.

Figure 4

Changes in mRNA levels for pro-inflammatory transcripts in human dermal microvascular endothelial cells (HDMECs) treated with 10% patient serum for four hours. Serum from pre-CPB (T1), post-CPB (T2) and 18 hours after CPB (T3) were assessed with saline treated (negative control) and TNF treated (positive control). E-selectin, IL-6 (both markers of NF-κB mediated endothelial activation) and angpt-2 expression were significantly different between control groups and patient samples (A, B, C) while vascular-endothelial growth factor (VEGF) expression was not significantly changed (D) Most importantly, no significant differences were observed between T1, T2 or T3 sera. Compilation of three different patient sera experiments run in duplicate, p values indicated.