1.
Association of CTC status (positive if ≥1 CTC/7.5 mL blood) and tumor characteristics
| Variables | n (%) | Positive rate
(%) |
P | ||
| All patients
(N=264) |
CTC-negative
(N=236) |
CTC-positive
(N=28) |
|||
Age (
 ) (year)
|
48.6±11.3 | 48.1±11.3 | 52.3±11.4 | 0.068* | |
| Median time after surgery
(IQR) (month) |
19.0 (7.8–33.0) | 20.0 (8.0–33.0) | 16.0 (7.0–28.0) | 0.308# | |
| Menopausal status | 0.098** | ||||
| Premenopausal | 160 (60.1) | 147 (62.3) | 13 (46.4) | 8.1 | |
| Postmenopausal | 103 (39.0) | 88 (37.3) | 15 (53.6) | 14.6 | |
| Unknown | 1 (0.4) | 1 (0.4) | 0 (0) | 0 | |
| Nodal status | 0.990** | ||||
| Negative | 170 (64.4) | 152 (64.4) | 18 (64.3) | 10.6 | |
| Positive | 94 (35.6) | 84 (35.6) | 10 (35.7) | 10.6 | |
| TNM stage | 0.772** | ||||
| I | 124 (47.0) | 111 (47.0) | 13 (46.4) | 10.5 | |
| II | 104 (39.4) | 94 (39.8) | 10 (35.7) | 9.6 | |
| III | 36 (13.6) | 31 (13.1) | 5 (17.9) | 13.9 | |
| Tumor size | 0.753** | ||||
| T1 | 154 (58.3) | 137 (58.1) | 17 (60.7) | 11.0 | |
| T2 | 94 (35.6) | 86 (36.4) | 8 (28.6) | 8.5 | |
| T3 | 15 (5.7) | 13 (5.5) | 2 (7.1) | 13.3 | |
| Unknown | 1 (0.4) | 0 (0) | 1 (3.6) | 100 | |
| Pathological type | 0.020** | ||||
| Ductal | 234 (88.6) | 213 (90.3) | 21 (75.0) | 9.0 | |
| Lobular | 9 (3.4) | 8 (3.4) | 1 (3.6) | 11.1 | |
| Other | 21 (8.0) | 15 (6.4) | 6 (21.4) | 28.6 | |
| Tumor grade | 0.620** | ||||
| 1 | 21 (8.0) | 20 (8.5) | 1 (3.6) | 4.8 | |
| 2 | 125 (47.3) | 111 (47.0) | 14 (50.0) | 11.2 | |
| 3 | 100 (37.9) | 91 (38.6) | 9 (32.1) | 9.0 | |
| Unknown | 18 (6.8) | 14 (5.9) | 4 (14.3) | 22.2 | |
| HR/HER2 status | 0.221** | ||||
| HR+/HER2+ | 43 (16.3) | 35 (14.8) | 8 (28.6) | 18.6 | |
| HR+/HER2– | 167 (63.3) | 153 (64.8) | 14 (50.0) | 8.4 | |
| HR–/HER2+ | 26 (9.8) | 24 (10.2) | 2 (7.1) | 7.7 | |
| HR–/HER2– | 28 (10.6) | 24 (10.2) | 4 (14.3) | 14.3 | |
| Ki 67 | 0.28±0.21 | 0.28±0.21 | 0.28±0.22 | 0.871* | |
| Endocrine therapy | 0.602** | ||||
| Yes | 200 (75.8) | 178 (75.4) | 22 (78.6) | 11.0 | |
| No | 55 (20.8) | 49 (20.8) | 6 (21.4) | 10.9 | |
| Unknown | 9 (3.4) | 9 (3.8) | 0 (0) | 0 | |
| Table 1 (continued) | |||||