3.

Correlation between baseline CTC status and peripheral lymphocyte subtypes distribution in first-line TNBC

Peripheral lymphocyte subtypes (Phenotype)	Correlation coefficient	P
CTC, circulating tumor cell; TNBC, triple-negative breast cancer. Baseline CTC status consists of CTC positivity (>2 CTC/2 mL) and CTC negativity (≤2 CTC/2 mL).
Total T-cells (CD3+)	–0.234	0.121
Helper T-cells (CD3+ & CD4 +)	–0.130	0.391
Cytotoxic T-cell (CD3+ & CD8 +)	–0.111	0.455
CD4+/CD8+ratio (CD4+/CD8+)	–0.102	0.528
Natural killer cell (CD3– & CD56 + & CD16 +)	0.321	0.032
Natural killer T-cell (CD3+ & CD56 + & CD16 +)	0.280	0.855
B cells (CD3– & CD19 +)	–0.008	0.957
Regulatory T-cells (CD4+ & CD25 +)	–0.220	0.143
Activated naïve cytotoxic T-cells (CD8+ & CD28 +)	–0.214	0.157
Suppressor T-cells (CD8+ & CD28 –)	0.276	0.064