S1.

Discription, phenotype and reference range of peripheral lymphocyte subsets

Peripheral lymphocyte subtypes	Molecular phenotype	Reference range (%)
Peripheral lymphocyte subtypes	Molecular phenotype	Low	Median	High
Total T-cells	CD3⁺	<62.72	62.72–78.30	>78.30
Helper T-cells	CD3⁺ & CD4 ⁺	<31.47	31.47–43.80	>43.80
Cytotoxic T-cell	CD3⁺ & CD8 ⁺	<19.22	19.22–34.80	>34.80
CD4⁺/CD8⁺ ratio	CD4⁺/CD8⁺	<0.98	0.98–1.94	>1.94
Natural killer cell	CD3^– & CD56 ⁺ & CD16 ⁺	<9.15	9.15–21.51	>21.51
Natural killer T-cell	CD3⁺ & CD56 ⁺ & CD16 ⁺	<1.05	1.05–6.05	>6.05
B cells	CD19⁺	<7.48	7.48–15.55	>15.55
Regulatory T-cells	CD4⁺ & CD25 ⁺	<1.36	1.36–5.48	>5.48
Activated naïve cytotoxic T-cells	CD8⁺ & CD28 ⁺	<7.74	7.74–16.33	>16.33
Suppressor T-cells	CD8⁺ & CD28 ^–	<9.16	9.16–23.28	>23.28