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. 2018 Jun;30(3):351–363. doi: 10.21147/j.issn.1000-9604.2018.03.07

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Menage a trois 1 (MAT1) correlates with the status of estrogen receptor (ER) and progesterone receptor (PR) in breast cancer. (A) Representative images of immunohistochemistry (IHC) staining for ER– vs. ER+ and PR– vs. PR+ breast cancer; (B) Statistical analysis on IHC scores revealed that there was no any significant difference in MAT1 protein amount between ER– and ER+ groups at whole level; (C) The protein abundance of MAT1 was positively correlated with the ER status at the absence of human epidermal growth factor receptor 2 (HER2)-enriched cases. The protein abundance of MAT1 was much higher in PR+ breast cancer than PR– tumors, no matter with HER2-strongly positive patients (D) or not (E). Expression analysis of Gene Expression Omnibus (GEO) accession GSE25066 also displayed that MAT1 mRNA expression was significantly higher in ESR1+ cancerous tissues than in ESR1– at the presence of ERBB2-positive patients (F) or not (G). The semi-quantitative results and public GEO dataset analysis are presented as .

Inline graphic — Menage a trois 1 (MAT1) correlates with the status of estrogen receptor (ER) and progesterone receptor (PR) in breast cancer. (A) Representative images of immunohistochemistry (IHC) staining for ER– vs. ER+ and PR– vs. PR+ breast cancer; (B) Statistical analysis on IHC scores revealed that there was no any significant difference in MAT1 protein amount between ER– and ER+ groups at whole level; (C) The protein abundance of MAT1 was positively correlated with the ER status at the absence of human epidermal growth factor receptor 2 (HER2)-enriched cases. The protein abundance of MAT1 was much higher in PR+ breast cancer than PR– tumors, no matter with HER2-strongly positive patients (D) or not (E). Expression analysis of Gene Expression Omnibus (GEO) accession GSE25066 also displayed that MAT1 mRNA expression was significantly higher in ESR1+ cancerous tissues than in ESR1– at the presence of ERBB2-positive patients (F) or not (G). The semi-quantitative results and public GEO dataset analysis are presented as .