Table 3. Relationships among ATM, p53, and Phospho-p53 (S15) Expressions and Patient Outcomes in ACC.
| Parameter | No. of patients | ATM loss in cancer | ATM loss in stroma | Positive expression of p53 expression | Positive expression of phospho-p53 (S15) |
|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | n (%) | |
| Sex | |||||
| Woman | 23 (47.9) | 15 (65.2) | 16 (69.6) | 16 (69.6) | 9 (39.1) |
| Man | 25 (52.1) | 13 (52) | 13 (52) | 22 (88) | 9 (36) |
| p value | 0.263 | 0.172 | 0.112 | 0.529 | |
| Age (years old) | |||||
| <55 | 26 (54.2) | 10 (38.5) | 14 (53.8) | 21 (80.8) | 9 (34.6) |
| ≥55 | 22 (45.8) | 18 (81.8) | 15 (68.2) | 17 (77.3) | 9 (40.9) |
| p value | 0.003 | 0.238 | 0.521 | 0.440 | |
| Tumor site | |||||
| Parotid gland | 3 (6.3) | 1 (33.3) | 2 (66.7) | 3 100) | 0 (0) |
| Submandibular gland | 8 (16.7) | 4 (50) | 5 (62.5) | 6 (75) | 6 (75) |
| Sublingual gland | 1 (2.1) | 1 (100) | 1 (100) | 1 (100) | 1 (100) |
| Palate | 23 (47.9) | 14 (60.9) | 15 (65.2) | 17 (73.9) | 8 (34.8) |
| Upper lip | 2 (4.2) | 1 (50) | 1 (50) | 2 100) | 1 (50) |
| Lower lip | 1 (2.1) | 0 (0) | 0 (0) | 1 100) | 0 (0) |
| Tongue | 2 (4.2) | 2 (100) | 1 (50) | 2 100) | 0 (0) |
| Buccal | 1 (2.1) | 0 (0) | 0 (0) | 1 100) | 0 (0) |
| Retromolar area | 1 (2.1) | 0 (0) | 0 (0) | 1 100) | 0 (0) |
| Floor of mouth | 6 (12.5) | 5 (83.3) | 4 (66.7) | 4 (66.7) | 2 (33.3) |
| p value | 0.475 | 0.863 | 0.992 | 0.219 | |
| Histology | |||||
| Solid | 13 (27.1) | 10 (76.9) | 8 (61.5) | 7 (53.8) | 4 (30.8) |
| Tubular and cribriform | 35 (72.9) | 18 (51.4) | 21 (60) | 31 (88.6) | 14 (40) |
| p value | 0.102 | 0.597 | 0.016 | 0.406 | |
| Perineural invasion | 29 (60.4) | 17 (58.6) | 22 (75.9) | 23 (79.3) | 11 (37.9) |
| 0.597 | 0.008 | 0.624 | 0.592 | ||
| Distant metastasis | 18 (37.5) | 13 (72.2) | 14 (77.8) | 13 (72.2) | 6 (33.3) |
| 0.113 | 0.053 | 0.287 | 0.442 | ||
| Death due to ACC | 5 (11.6) | 5 (100) | 3 (60) | 5 (100) | 0 (0) |
| 0.057 | 0.667 | 0.293 | 0.083 | ||
| Total patients | 48 (100) | 28 (58.3) | 29 (60.4) | 38 (79.2) | 18 (37.5) |
ATM, ataxia telangiectasia mutated; ACC, adenoid cystic carcinoma.
p values from Fisher's exact test are provided.