. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Clin Pharmacol Ther. 2018 Feb 8;104(5):949–956. doi: 10.1002/cpt.1014

Table 2.

Results from GWAS, meta-analysis and replication for association with ATV hair level in WIHS.

rsID	Genotyped or Imputed	Chr.	Position^*	A1/A2 allele	MAF	Ethnic group (n)	Fold difference (95% CI)	P
rs73208473	Imputed	4	7324596	A/C	0.118	AA (194)	0.54 (0.37–0.80)	0.0025
					0.319	WT (57)	0.34 (0.24–0.51)	3.09x10⁻⁶
					0.119	HIS (53)	0.91 (0.34–2.37)	0.84
						Meta-analysis (300)	0.46 (0.35–0.61)	1.71x10⁻⁸

rs73208470	Genotypes	4	7323913	G/C	0.143	AA (194)	0.61 (0.44–0.86)	0.0055
					0.324	WT (57)	0.34 (0.24–0.51)	3.09x10⁻⁶
					0.119	HIS (53)	0.91 (0.34–2.37)	0.84
						Meta-analysis (300)	0.50 (0.39–0.65)	8.04x10⁻⁸

Position is based on GRCh37/hg19 assembly.

Descriptions: Minor/major alleles (A1/A2); African American (AA); Linear regression coefficient for the ATV concentration in nanograms of ATV per milligram of hair (β); Chromosome (Chr); Confidence interval (CI); Hispanic (HIS); White (WT).