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. 2018 Jul 9;9:2655. doi: 10.1038/s41467-018-05184-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Gut microbiota associations with common diseases in TwinsUK. a Counts of afflicted and unafflicted individuals for common diseases within the subset of TwinsUK individuals having gut microbiota profiles. b Correlation between the diseases when comparing those with complete data in each pairwise comparison. Phi is equivalent to Pearson’s correlation for binary variables. Breast cancer and acne are not included as they had correlation coefficients of <0.1 with all other diseases. Data overlap in each case can be found in Supplementary Data 6. c The number of associations observed with gut microbiota markers for each disease. Colour represents the direction of the association and darker bars represent those significant after FDR adjustment. d The number of afflicted individuals in the study plotted against the number of nominally significant associations observed (p < 0.05) for each disease