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. 2018 Jul 9;9(7):764. doi: 10.1038/s41419-018-0772-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a (I-II, breast cancer; III colon cancer; IV kidney cancer) Survival analysis of NKA genes expression. b (I, adenocortical carcinoma; II, brain cancer; III breast cancer) Survival analysis of SERCA genes expression. c Effect of Graviola extract in MIA PaCa-2 xenografts. MIA PaCa2 at an inoculation density of 1 × 10⁶ cells/injection was injected subcutaneously into the axillary region of female NOD/SCID mice (age 8–10 weeks). When tumors reached ~200 mm, three animals were randomized into three groups (untreated, carrier, and Graviola treated), where each one consisted of eight mice and administrations were started. Graviola extract was administered at a dose of 25 mg/kg in a 5% Cremophore ELP/10% DMSO/NS and a 5 days on/2 days off schedule (arrows show administrations, where numbers above the arrows show the days post tumor cell’s inoculation). Each point shows the mean ± SD. The experiment ended when tumors of the untreated mice reached a volume of about 2000 mm³ (~10% of mice’s weight)