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. 2018 Jul 9;9(7):765. doi: 10.1038/s41419-018-0819-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The red line shows the distribution of H1 around the nucleosome dyad. The black line showing the relationship between the position of adjacent nucleosomes. The right y axis shows the normalized nucleosome count with a dyad-to-dyad distance indicated on the x axis. The top schematic diagram shows the H1 (red) placement on nucleosomes (black oval). b H1 occupancy is positively correlated with nucleosome occupancy. c H1 locates at borders of nucleosomes with top 10,000 occupancy whereas H1 is depleted on nucleosomes with bottom 10,000 occupancy. All these nucleosomes have fuzziness of 30–35 to remove the impact of fuzziness. d H1 locates at borders and midpoint of nucleosomes with top 10,000 fuzziness whereas H1 only locates at borders of nucleosomes with bottom 10,000 fuzziness. All these nucleosomes have normalized read count of 0.8–1.2 to remove the impact of occupancy