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. 2018 Jul 9;8:10327. doi: 10.1038/s41598-018-28593-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depiction of the relative effect of FR on plasma angiotensin (Ang) peptides. Shown is the RAS fingerprint of Ang peptides in CT (n = 10) (A,C) and FR (n = 11) (B,D) female rats before (A,B) and after Ang-[1–10] infusion (C,D) (n = 8/group). The numbers in parentheses refer to the specific Ang peptide with the peptide concentration (pg/mL) listed below each peptide. For example, (1–10) represents Ang-[1–10]. Red and green circles reflect biologically active and inactive Ang peptides, respectively. The relative amounts of plasma peptides are depicted by the circle volumes, which are drawn to a relative scale.