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. 2018 Jul 9;8:10310. doi: 10.1038/s41598-018-28496-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of glp-1r localization and average liraglutide^VT750 distribution. (a) Concept behind aligning a 2D histology ISH image (right) with 3D LSFM data (left). A histology image was aligned to an interpolated section of the integrated brain atlas template. Once aligned a similar interpolated projection from the average liraglutide^VT750 distribution signal could be generated. Example ISH section with zoom panel at SO region. Red color indicates cells positive for glp-1r. (b) Heat map (blue) representation of ISH section from (a) aligned with the average liraglutide^VT750 signal (pink) from Fig. 2c. The signals are overlaid onto separate halves of the CCFv3 template³.