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. 2018 Jul 9;8:10310. doi: 10.1038/s41598-018-28496-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparing brain connectivity maps with whole brain c-Fos data. (a) Top: Part of primary injection site (CEA) in a Prkcd-GluCla-CFP-IRES-Cre mouse. Bottom: Part of primary injection site (PB) in a slc17ac cre mouse. ©2011 Allen Institute for Brain Science. Allen Mouse Brain Connectivity atlas. Available from: connectivity.brain-map.org. (b) Connectivity maps visualized by horizontal maximum intensity projection overlaid with the average c-Fos increase following liraglutide administration from Fig. 5e. (c) Coronal projection images showing downloaded glutamatergic projections from PB, and PKD-delta+ projections from CEA, together with the average c-Fos increase following liraglutide administration. Signals are overlaid onto the CCFv3 template³.