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. 2018 Jul 3;8:239. doi: 10.3389/fonc.2018.00239

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Copyright © 2018 Warren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnetic resonance imaging demonstrating (A) non-enhancing tumor at diagnosis (left) and enhancement (right) following radiation therapy; (B) tumor necrosis (enhancement at diagnosis, left) and FLAIR image (right) showing extent of tumor beyond area of enhancement, and (C) intratumoral cysts. Areas of contrast enhancement do not represent tumor burden in diffuse intrinsic pontine glioma and do not ensure adequate drug delivery.