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. 2018 Jul 9;9:2650. doi: 10.1038/s41467-018-05026-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Development of iNKT cell subsets in DO11.10 TCRβ transgenic mice on the C57BL/6 or C57BL/6 × BALB/c F1 background. a The thymi of 8-week-old C57BL/6, C57BL/6 DO11.10 TCRβ transgenic, BALB/c, C57BL/6 × BALB/c F1, and BALB/c × C57BL/6 DO11.10 TCRβ transgenic mice were stained with anti-CD24 mAbs, PBS57–CD1d tetramers and mAbs specific for the transcription factors PLZF, Rorγt, and Tbet. Representative flow cytometry plots for the frequency of total mature iNKT cells and iNKT subsets in each genotype is shown. b Summary of the data shown in a with three mice per group. Data are mean ± SD. Significance was assessed using multiple comparison one-way analysis of variance (ANOVA) *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant. For clarity purposes, the only statistics shown are between mice with or without expression of the DO11.10 TCR transgene for a given genetic background