Table 1.
Genetic and phenotypic characteristics of K. pneumoniae strains isolated from different specimen types at different dates
| Strain ID | Source | Isolation date | Medical events | Antibiotics used | Prevailing symptoms | MIC (μg/ml) | MLST/PFGE | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IMP | MEM | FEP | FOS | AMK | LEV | CST | SCF | TIG | ISE | |||||||
| KP1 | Feces | 20/11/14 | Third chem | MEM, ISE | FEV | <0.5 | <0.5 | 32 | >256 | <256 | >256 | 0.5 | <0.5 | 0.5 | >128 | ST1/KP1 |
| KP2 | Feces | 28/11/14 | Third chem | MEM, ISE, VAN | FEV, DIA | 128 | 128 | >256 | >256 | >256 | 256 | 0.5 | >256 | 0.5 | >128 | ST11/KP2 |
| KP3 | Feces | 05/05/15 | TRAN | MEM, FOS, TIG | FEV, BDIA | 128 | 128 | >256 | >256 | >256 | 256 | 0.25 | >256 | 0.5 | >128 | ST11/KP2 |
| KP4 | Blood | 11/05/15 | TRAN | MEM, FOS, TIG | HFEV, DIA | >128 | >128 | >256 | >256 | >256 | 256 | 0.25 | >256 | 1 | >128 | ST11/KP2 |
| KP5 | Blood | 18/05/15 | TRAN | MEM, FOS, TIG | HFEV, DIA | 128 | 64 | >256 | >256 | >256 | 256 | 0.25 | >256 | 1 | >128 | ST11/KP2 |
| KP6 | Blood | 24/05/15 | TRAN | MEM, FOS, TIG | HFEV, DIA | >128 | 128 | >256 | >256 | >256 | 256 | 0.25 | >256 | 1 | >128 | ST11/KP2 |
| KP7 | Feces | 29/05/15 | TRAN | MEM, IMP, TIG | FEV, LLA, DIA | 64 | 32 | >256 | >256 | >256 | >256 | 0.5 | 256 | 1 | >128 | ST11/KP2 |
| KP8 | Blood, Feces | 06/07/15 | – | CST (IV) | FEV, DIA | 64 | 64 | 128 | >256 | >256 | >256 | 0.25 | >256 | 1 | >128 | ST11/KP2 |
| KP9 | Sputum | 27/10/15 | – | MEM, LZD, CST | SU | 128 | 128 | >256 | >256 | >256 | >256 | 0.25 | 256 | 8 | >128 | ST11/KP2 |
| KP10 | Feces | 13/11/15 | – | MEM, LZD, CST | SU | 64 | 64 | 128 | >256 | >256 | >256 | 32 | 256 | 8 | >128 | ST11/KP2 |
| KP11 | Sputum | 04/11/15 | Follow up | CST, PMB, MEM | PNEU, DIA | 64 | 64 | >256 | >256 | >256 | >256 | 32 | 256 | 4 | >128 | ST11/KP2 |
| KP12 | Feces | 10/10/16 | Follow up | No | No | 64 | 32 | >256 | >256 | >256 | >256 | 32 | 256 | 4 | >128 | ST11/KP2 |
| KP13 | Feces | 16/02/17 | Follow up | No | No | 64 | 64 | 128 | >256 | >256 | 64 | 32 | 256 | 4 | >128 | ST11/KP2 |
| KP14 | Feces | 05/05/17 | Follow up | No | No | 64 | 64 | >256 | >256 | >256 | 64 | 64 | 256 | 4 | >128 | ST11/KP2 |
| KP15 | Feces | 12/07/17 | Follow up | No | No | 64 | 32 | >256 | >256 | >256 | >256 | 64 | 256 | 4 | >128 | ST11/KP2 |
| KP16 | Feces | 25/08/17 | Follow up | No | No | 64 | 64 | >256 | >256 | >256 | >256 | 64 | 256 | 4 | >128 | ST11/KP2 |
| KP17 | Feces | 18/10/17 | Follow up | No | No | 64 | 64 | >256 | >256 | >256 | 64 | 64 | 256 | 8 | >128 | ST11/KP2 |
Bolded values represent resistance to colistin or tigecycline. chem chemotherapy; TRAN hematopoietic stem cell transplantation, FEV fever, HFEV high fever, BDIA bloody diarrhea, DIA diarrhea, PNEU pneumonia, LLA liver lobe abscess, SU sacrococcygeal ulcer, MEM meropenem, ISE isepamicin, VAN vancomycin, TIG tigecycline, FOS fosfomycin, IMP imipenem, CST colistin, LZD linezolid, PMB polymyxin B, FEP cefepime, AMK amikacin, LEV levofloxacin, SCF cefperazone/sulbactam