Table 3.
Univariate and multivariate logistic regression analysis of risk factors associated with 30-day mortality.
| Variable | Univariate analysis | Multivariate analysis† | ||
|---|---|---|---|---|
| Odds ratio (95% CI) | p-Value | Odds ratio (95% CI) | p-Value | |
| Age | 1.026 (1.005–1.048) | 0.016 | 1.035 (1.006–1.064) | 0.016 |
| Baseline serum creatinine | 1.007 (1.003–1.012) | 0.001 | – | – |
| Base excess | 0.788 (0.720–0.863) | <0.001 | 0.867 (0.782–0.960) | 0.006 |
| NIHSS | 1.124 (1.075–1.176) | <0.001 | – | – |
| SOFA | 1.733 (1.526–1.969) | <0.001 | 1.540 (1.324–1.792) | <0.001 |
| Albumin | 0.925 (0.885–0.966) | <0.001 | – | – |
| Vasopressors | 17.535 (7.713–39.867) | <0.001 | – | – |
| Mechanical ventilation | 15.961 (8.438–30.191) | <0.001 | 2.705 (1.183–6.189) | 0.018 |
| Acute kidney injury | 10.099 (4.921–20.722) | <0.001 | – | – |
| New-onset hyperchloremia* | 2.583 (1.206–5.533) | 0.015 | – | – |
| [Cl−]0 (per 5 mmol/L)* | 1.502 (1.168–1.932) | 0.002 | – | – |
| [Cl−]max (per 5 mmol/L)* | 1.657 (1.368–2.007) | <0.001 | – | – |
| Δ[Cl−] (per 5 mmol/L)* | 1.552 (1.235–1.951) | <0.001 | – | – |
*
The indicators of chloride were drawn into multivariable logistic analysis separately.
†
Since age, base excess, SOFA, and mechanical ventilation were consistently found to be independent factors associated with 30-day mortality when each indicator of chloride was included, their odds ratio value and p-value were given when new-onset hyperchloremia was drawn in multivariate analysis only. GCS was not included in the multivariate model because of collinearity with the NIHSS. Serum creatinine was not included in the multivariate model because of collinearity with the acute kidney injury. CI, confidence interval.