Table 4.
Univariate and multivariate logistic regression analysis of risk factors associated with 6-month poor outcome (mRS ≥ 4).
| Variable | Univariate analysis | Multivariate analysis† | ||
|---|---|---|---|---|
| Odds ratio (95% CI) | p-Value | Odds ratio (95% CI) | p-Value | |
| Age | 1.032 (1.016–1.047) | <0.001 | 1.038 (1.019–1.057) | <0.001 |
| Diabetes mellitus | 1.669 (1.018–2.736) | 0.042 | – | – |
| NIHSS | 1.143 (1.103–1.184) | <0.001 | 1.087 (1.041–1.136) | <0.001 |
| SOFA | 1.439 (1.323–1.565) | <0.001 | 1.308 (1.191–1.437) | <0.001 |
| Albumin | 0.926 (0.894–0.959) | <0.001 | – | – |
| Vasopressors | 11.028 (3.780–32.172) | <0.001 | – | – |
| Mechanical ventilation | 5.544 (3.307–9.293) | <0.001 | – | – |
| Acute kidney injury | 3.394 (1.660–6.941) | 0.001 | – | – |
| New-onset hyperchloremia* | 3.394 (1.660–6.941) | 0.001 | – | – |
| [Cl−]0 (per 5 mmol/L)* | 1.203 (0.995–1.453) | 0.056 | – | – |
| [Cl−]max (per 5 mmol/L)* | 1.425 (1.205–1.685) | <0.001 | – | – |
| Δ[Cl−] (per 5 mmol/L)* | 1.383 (1.143–1.674) | 0.001 | – | – |
*
The indicators of chloride were drawn into multivariable logistic analysis separately.
†
Since age, NIHSS, and SOFA were consistently found to be independent factors associated with 30-day mortality when each indicator of chloride was included, their odds ratio value, and p-value were given when new-onset hyperchloremia was drawn in multivariate analysis only. GCS was not included in the multivariate model because of collinearity with the NIHSS. CI, confidence interval.