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. 2018 Jul 3;5:195. doi: 10.3389/fmed.2018.00195

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Copyright © 2018 Gauberti, Potzeha, Vivien and Martinez de Lizarrondo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the main roles of bradykinin in the Neurovascular Unit via B1- and B2- Receptors. Endothelium (with tight junctions), astrocytes, neurons, oligodendrocytes, microglia, and pericytes compose the neurovascular unit. BBB, blood-brain barrier; BK, bradykinin; HMWK, High molecular Weight Kininogen; Plg, plasminogen; tPA, tissue-type plasminogen activator.