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. 2018 Jul 9;8:10344. doi: 10.1038/s41598-018-28690-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ATM- and DNA-PKcs-independent recruitment of Topo IIβ to DSB sites. (A) Recruitment of Topo IIβ to DSB sites in ATM-deficient cells. HeLa and ATM-deficient AT5 cells were microirradiated with a pulsed UVA laser. After 10 min incubation at 37 °C, the cells were fixed and immunostained for Topo IIβ and phosphorylated serine 1981 (pS1981) of ATM. (B) Recruitment of Topo IIβ to DSB sites in DNA-PKcs-deficient cells. The DNA-PKcs-proficient M059K and -deficient M059J cells were subjected to laser microirradiation followed by immunostaining for Topo IIβ and phosphorylated serine 2056 (pS2056) of DNA-PKcs.